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AKR1C3

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
Aldo-Keto Reductase Family 1 Member C3
Function
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942, PubMed:11165022). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:15047184, PubMed:20036328, PubMed:10622721, PubMed:11165022, PubMed:10998348, PubMed:19010934). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:14672942, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:10557352). Displays also retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338).
Biological Process
Cellular response to cadmium ion Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to corticosteroid stimulus Source: UniProtKB
Cellular response to jasmonic acid stimulus Source: UniProtKB
Cellular response to prostaglandin D stimulus Source: UniProtKB
Cellular response to prostaglandin stimulus Source: UniProtKB
Cellular response to reactive oxygen species Source: UniProtKB
Cellular response to starvation Source: UniProtKB
Cyclooxygenase pathway Source: Reactome
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Farnesol catabolic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Macromolecule metabolic process Source: UniProtKB
Male gonad development Source: UniProtKB
Negative regulation of retinoic acid biosynthetic process Source: UniProtKB
Positive regulation of cell death Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of endothelial cell apoptotic process Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: UniProtKB
Progesterone metabolic process Source: UniProtKB
Prostaglandin metabolic process Source: UniProtKB
Regulation of retinoic acid receptor signaling pathway Source: UniProtKB
Regulation of testosterone biosynthetic process Source: UniProtKB
Renal absorption Source: UniProtKB
Response to nutrient Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoid metabolic process Source: Reactome
Retinol metabolic process Source: GOC
Steroid metabolic process Source: UniProtKB
Testosterone biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm

Anti-AKR1C3 antibodies

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Target: AKR1C3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-31918
Application*: WB, IP, IF, E
Target: AKR1C3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-639398
Application*: WB, FC, ICC/IF, IP
Target: AKR1C3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180479
Application*: IF, IH, WB
Target: AKR1C3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-12560
Application*: E, P, WB
Target: AKR1C3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-12559
Application*: F, IF, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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