Apoptosis is a kind of programmed cell death (PCD) that plays a fundamental role in genomic DNA fragmentation, cell membrane blebbing, chromatin condensation and exposure of specific phagocytosis signaling molecules on the cell surface. There are two major signaling pathways that lead to apoptosis: the intrinsic pathway and the extrinsic pathway. In the intrinsic pathway, the cell kills itself because it senses cell stress. The extrinsic pathway is initiated when death receptors at the cell surface encounter specific cognate “death ligands”, which can activate caspases within seconds of ligand binding.
Fig.1 Apoptosis signaling pathways.1
Further studies in apoptosis signal pathway will undoubtedly reveal novel information that advance our understanding of its regulatory mechanisms and treatment of diseases, such as neurodegenerative diseases, cancer, or autoimmunity. Creative Biolabs offers apoptosis signal pathway phosphorylation screening service with antibody array, which consists of 214 high-specific antibodies and more than 110 phosphorylation sites involved in apoptosis signal pathways can be tested.
Signal Pathways | |
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Targets |
14-3-3 theta/tau (S232) | CASP6 (S257) | HSP27 (S78) | NFkB-p65 (S529) |
14-3-3 zeta (S58) | CASP8 (S347) | HSP27 (S82) | NFkB-p65 (S536) |
14-3-3 zeta/delta (T232) | CASP9 (T125) | HSP90B (S254) | NFkB-p65 (T254) |
AKT (S473) | CASP9 (S144) | NFKBIA (S32/S36) | p53 (S37) |
AKT (T308) | CASP9 (S196) | NFKBIA (Y42) | p53 (S392) |
AKT1 (T72) | CASP9 (Y153) | NFKBIB (T19) | p53 (S6) |
AKT1 (Y474) | CASP3 (S150) | NFKBIE (S22) | p70S6K (S411) |
AKT2 (S474) | CDK1 (Y15) | CHUK (T23) | p70S6K (S424) |
A-RAF (Y301/Y302) | CDK1 (T14) | IKBKB (Y188) | p70S6K (T229) |
ASK1 (S83) | Chk1 (S280) | IKBKB (Y199) | p70S6K (T389) |
ASK1 (S966) | Chk1 (S286) | IKBKG (S85) | p70S6k (T421) |
ATRIP (S68/S72) | Chk1 (S317) | IKKa/b (S180/S181) | p70S6K (S371) |
BAD (S112) | Chk1 (S345) | IKBKG (S31) | p70S6K (S418) |
BAD (S134) | Chk2 (S516) | JNK1/2/3 (T183/Y185) | RPS6KB1 (S423) |
BAD (S136) | Chk2 (T383) | Lamin A/B (S392) | P90RSK (S380) |
BAD (S155) | Chk2 (T387) | Lamin A/C (S22) | P90RSK (T359/S363) |
BAD (S91/S128) | Chk2 (T68) | MAP2K7 (S271) | P90RSK (T573) |
BCL2 (S70) | c-Jun (S243) | MAP2K7 (T275) | PIK3R1/PIK3R3 (Y467/Y199) |
BCL2 (S87) | c-Jun (T91) | NFkB-p100 (S872) | PKA CAT (T197) |
BCL2 (T56) | DAXX (S668) | NFkB-p100/p52 (S865) | PKC pan activation site |
BCL2 (T69) | Erk1/2 (T202) | NFkB-p100/p52 (S869) | PTEN (S370) |
BCL-XL (S62) | Erk1/2 (Y204) | NFkB-p105 (S927) | PTEN (S380) |
BCL-XL (T47) | FADD (S194) | NFkB-p105/p50 (S337) | PTEN (S380/T382/T383) |
BID (S78) | FKHR (S256) | NFkB-p105/p50 (S893) | SAPK/JNK (T183) |
BIM (S69/S65) | FKHR (S319) | NFkB-p105/p50 (S907) | SAPK/JNK (Y185) |
B-RAF (S446) | FOXO1/3/4 pan (T24/T32) | NFkB-p105/p50 (S932) | Survivin (T117) |
B-RAF (S601) | FOXO1A (S329) | NFkB-p65 (S276) | TAK1 (T184) |
B-RAF (T598) | HSP90AB1 (S226) | NFkB-p65 (S311) | XIAP (S87) |
CaMKII (T286) | HSP27 (S15) | NFkB-p65 (S468) |
For more detailed information about our antibody arrays, please feel free to contact us.
Reference