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Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ)


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Published Data
CBMAB-0137CQ-1
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ) in IF
Immunofluorescence staining showing excitatory (CaMKII-α) and inhibitory (Parvalbumin) neurons in the hippocampus. The insets show higher magnification of positive cells (arrowheads). ...View More
Yang, F., Yang, L., Wataya-Kaneda, M., Teng, L., & Katayama, I. (2020). Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model. Plos one, 15(1), e0228204.
CBMAB-0137CQ-2
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ) in Immunoblot
Activation of TRKB signaling in ∆K280 TauRD-DsRed SH-SY5Y cells. p-TRKB (Y516 and Y817), TRKB, p-AKT (S473), AKT, p-CaMKII (T286), CaMKII, p-ERK (T202/Y204), ERK, p-RSK (S380), RSK, p-CREB (S133), CREB, BDNF (pro- and mature), BCL2, BAX and CASP3 levels analysed by immunoblotting using GAPDH as a loading control (n = 3). ...View More
Weng, Z. K., Lin, T. H., Chang, K. H., Chiu, Y. J., Lin, C. H., Tseng, P. H., ... & Chen, C. M. (2023). Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer's Disease Treatment Strategy. Biomolecules, 13(2), 219.
CBMAB-0137CQ-3
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ) in WB
Representative Western blotting bands of the cognition- and spatial learning-related proteins (P-CaMKII)/CaMKII, (P-CREB)/CREB ratios. ...View More
Li, Q., Shi, Y., Li, X., Yang, Y., Zhang, X., Xu, L., ... & Wu, L. (2022). Proteomic-based approach reveals the involvement of apolipoprotein AI in related phenotypes of autism spectrum disorder in the BTBR mouse model. International Journal of Molecular Sciences, 23(23), 15290.
CBMAB-0137CQ-4
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ) in WB
Western blottings showing increased NR2A and NR2B subunits of NMDAR and enhanced CaMKIIα activation in the PSD of the NMD mice ACC, compared with CON mice ACC. ...View More
Xu, Q. Y., Zhang, H. L., Du, H., Li, Y. C., Ji, F. H., Li, R., & Xu, G. Y. (2022). Identification of a glutamatergic claustrum-anterior cingulate cortex circuit for visceral pain processing. Journal of Neuroscience, 42(43), 8154-8168.
CBMAB-0137CQ-5
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ) in WB
Western blots showing reduced cLTP-induced CaMKIIα activation in Src3+/− slices, compared with WT slices. ...View More
Zhang, H. L., Zhao, B., Yang, P., Du, Y. Q., Han, W., Xu, J., & Yin, D. M. (2021). Steroid receptor coactivator 3 regulates synaptic plasticity and hippocampus-dependent memory. Neuroscience Bulletin, 37(12), 1645-1657.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0032
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of human CaMKII-α protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase II Alpha
Introduction
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
Entrez Gene ID
Human815
Mouse12322
Rat25400
UniProt ID
HumanQ9UQM7
MouseP11798
RatP11275
Alternative Names
Calcium/Calmodulin-Dependent Protein Kinase II Alpha; Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha; Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain; Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit; CaM Kinase II Alpha Subunit; CaM Kinase II Subunit Alpha; CaM-Kinase II Alpha Chain; CaMK-II Alpha Subunit; CaMK-II Subunit Alpha; EC 2.7.11.17; CAMKA; CaMKIINalpha; EC 2.7.11; KIAA0968
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity).
Regulates dendritic spine development (PubMed:28130356).
Also regulates the migration of developing neurons (PubMed:29100089).
Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
Biological Process
Angiotensin-activated signaling pathway Source: UniProtKB
Calcium ion transport Source: ParkinsonsUK-UCL
Dendritic spine development Source: UniProtKB
G1/S transition of mitotic cell cycle Source: ParkinsonsUK-UCL
Interferon-gamma-mediated signaling pathway Source: Reactome
MAPK cascade Source: Reactome
Negative regulation of hydrolase activity Source: UniProtKB
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Peptidyl-threonine autophosphorylation Source: UniProtKB
Positive regulation of calcium ion transport Source: ParkinsonsUK-UCL
Positive regulation of cardiac muscle cell apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Protein autophosphorylation Source: ParkinsonsUK-UCL
Protein phosphorylation Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of endocannabinoid signaling pathway Source: UniProtKB
Regulation of mitochondrial membrane permeability involved in apoptotic process Source: ParkinsonsUK-UCL
Regulation of neuronal synaptic plasticity Source: ParkinsonsUK-UCL
Regulation of neuron migration Source: UniProtKB
Regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
Regulation of NMDA receptor activity Source: Reactome
Response to ischemia Source: ParkinsonsUK-UCL
Wnt signaling pathway, calcium modulating pathway Source: Reactome
Cellular Location
Synapse; Postsynaptic density; Dendritic spine; Dendrite. Postsynaptic lipid rafts.
Involvement in disease
Mental retardation, autosomal dominant 53 (MRD53): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Mental retardation, autosomal recessive 63 (MRT63): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT63 patients manifest global developmental delay, severe intellectual disability, and seizures.
PTM
Autophosphorylation of Thr-286 following activation by Ca2+/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.
Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
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For research use only. Not intended for any clinical use.

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