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PDE4D

PDE4D is one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Full Name
Phosphodiesterase 4D
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Biological Process
Adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rateIC:BHF-UCL
Adrenergic receptor signaling pathwayISS:BHF-UCL
cAMP catabolic processManual Assertion Based On ExperimentIBA:GO_Central
cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Cellular response to cAMPIDA:BHF-UCL
Cellular response to epinephrine stimulusIDA:BHF-UCL
Establishment of endothelial barrierISS:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of heart contractionBy SimilarityISS:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationBy SimilarityISS:BHF-UCL
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-5 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionBy SimilarityISS:BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction1 PublicationIC:BHF-UCL
Regulation of heart rateBy SimilarityISS:BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumBy SimilarityISS:BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activityBy SimilarityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Apical cell membrane
Cytoplasm
Membrane
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity).
Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Involvement in disease
Acrodysostosis 2, with or without hormone resistance (ACRDYS2):
A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.
PTM
Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity).
Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.

Anti-PDE4D antibodies

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Target: PDE4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 5-13.4
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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