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Mouse Anti-PDE4D Recombinant Antibody (5-13.4) (CBMAB-0231-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
5-13.4
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Peptide: SLRENLLQHEKSKTARKSVS
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphodiesterase 4D
Introduction
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. The protein hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Entrez Gene ID
Human5144
Rat24627
UniProt ID
HumanQ08499
RatP14270
Alternative Names
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Biological Process
Adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rateIC:BHF-UCL
Adrenergic receptor signaling pathwayISS:BHF-UCL
cAMP catabolic processManual Assertion Based On ExperimentIBA:GO_Central
cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Cellular response to cAMPIDA:BHF-UCL
Cellular response to epinephrine stimulusIDA:BHF-UCL
Establishment of endothelial barrierISS:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of heart contractionBy SimilarityISS:BHF-UCL
Negative regulation of peptidyl-serine phosphorylationBy SimilarityISS:BHF-UCL
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-5 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionBy SimilarityISS:BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction1 PublicationIC:BHF-UCL
Regulation of heart rateBy SimilarityISS:BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumBy SimilarityISS:BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activityBy SimilarityISS:BHF-UCL
Regulation of signaling receptor activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Apical cell membrane
Cytoplasm
Membrane
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity).
Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Involvement in disease
Acrodysostosis 2, with or without hormone resistance (ACRDYS2):
A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.
PTM
Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity).
Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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