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LMNB1

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.
Full Name
lamin B1
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Biological Process
Nuclear envelope organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus lamina
Involvement in disease
Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD):
A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
Microcephaly 26, primary, autosomal dominant (MCPH26):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH26 is an autosomal dominant, progressive form apparent at birth or in early infancy. It is associated with relative short stature, variable severity of intellectual disability, and neurological features as the core symptoms. Brain imaging shows a simplified gyral pattern of the cortex and abnormal corpus callosum in some patients.
PTM
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Anti-LMNB1 antibodies

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Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A913
Application*: ELISA, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CF269
Application*: ELISA, WB, IF, FC, IP
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB217A
Application*: ELISA, WB, IP
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB306
Application*: WB, IP
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig
Clone: D4Q4Z
Application*: WB
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: D9V6H
Application*: WB, IP
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4B10
Application*: WB, E
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4E4
Application*: WB, E
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-383
Application*: E, IF, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBYCL-384
Application*: E, F, IC, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken
Clone: CBYCL-382
Application*: E, IF, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken, Human, Mouse, Rat
Clone: CBYJL-2588
Application*: E, F, IF, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken, Human, Mouse, Rat
Clone: E-3
Application*: IC, IF
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken, Human, Mouse, Rat
Clone: CBYJL-2587
Application*: E, IF, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken
Clone: 3G175
Application*: E, IF, IP, WB
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBYJL-1860
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJL-1859
Application*: E, P, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJL-1858
Application*: WB, IP, IF, E
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: ZL-6
Application*: E, IC, IF, IP, WB
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Chicken
Clone: ZL-5
Application*: WB, E, IC, IF, IP
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Mouse, Rat
Clone: X223
Application*: IC, IF, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Mouse, Pig, Frog, Zebrafish
Clone: LN43
Application*: F, IF, C, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GT144
Application*: IC, IF, P, IP, WB
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1857
Application*: IC, IF
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJL-1855
Application*: WB
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBYJL-1854
Application*: WB, IP
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJL-1853
Application*: WB, IP, IF
Target: LMNB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig
Clone: CBYJL-1852
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1851
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJL-1850
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7C11
Application*: IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Monkey
Clone: 5G8-D3-H7
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJL-1849
Application*: WB, IP
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1848
Application*: E, IH, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1847
Application*: E, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Mouse, Frog
Clone: CBYJL-1846
Application*: F, IH, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle, Dog, Mouse, Rabbit, Rat, Sheep
Clone: CBYJL-1845
Application*: E, F, IC, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJL-1844
Application*: E, P, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBYJL-1842
Application*: E, F, IF, IH, IP, WB, siRNA
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Mouse, Frog
Clone: 2Q1130
Application*: F, IC, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1841
Application*: WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1840
Application*: WB, IH, IC, IF, IP, P
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Chicken, Mouse, Rat
Clone: 13A259
Application*: E, IF, IP, WB
Target: LMNB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Sheep, Rabbit, Cattle, Dog
Clone: 119D5-F1
Application*: WB, DB, E, F, IC, IF, IH
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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