VSTM1

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Vascular Cell Adhesion Molecule 1

Isoform 2
Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1
Inhibitory immune receptor involved in the regulation of phagocytes.

Biological Process immune system process Source:UniProtKB-KW

Isoform 1
Membrane
Isoform 2
Secreted

Extracellular: 17-135
Helical: 136-156
Cytoplasmic: 157-236

Isoform 2 is N-glycosylated.