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Recombinant Mouse Anti-VSTM1 Antibody (CBHb325) (CBMAB-Hb973-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBHb325
Antibody Isotype
IgG1
Application
FC, FuncS, IP, WB

Basic Information

Immunogen
Purified SIRL-1-hIg fusion protein in PBS
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% BSA
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Vascular Cell Adhesion Molecule 1
Introduction
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Entrez Gene ID
284415
UniProt ID
Q6UX27
Alternative Names
Vascular Cell Adhesion Molecule 1; CD106 Antigen; INCAM-100; Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; CD106;
Function
Isoform 2
Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1
Inhibitory immune receptor involved in the regulation of phagocytes.
Biological Process
Biological Process immune system process Source:UniProtKB-KW
Cellular Location
Isoform 1
Membrane
Isoform 2
Secreted
Topology
Extracellular: 17-135
Helical: 136-156
Cytoplasmic: 157-236
PTM
Isoform 2 is N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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