IL1A

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

Interleukin 1 Alpha

Interleukin 1 Alpha

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Apoptotic process Source: ProtInc
Cellular response to heat Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Cellular sodium ion homeostasis Source: Ensembl
Connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
Cytokine-mediated signaling pathway Source: BHF-UCL
Ectopic germ cell programmed cell death Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Fever generation Source: UniProtKB-KW
Heart development Source: Ensembl
Immune response Source: InterPro
Inflammatory response Source: GO_Central
Keratinization Source: Ensembl
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of establishment of Sertoli cell barrier Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cytokine production Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Positive regulation of immature T cell proliferation in thymus Source: GO_Central
Positive regulation of interleukin-2 production Source: BHF-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of JNK cascade Source: Ensembl
Positive regulation of mitotic nuclear division Source: BHF-UCL
Positive regulation of neutrophil migration Source: Ensembl
Positive regulation of prostaglandin secretion Source: Ensembl
Positive regulation of protein secretion Source: AgBase
Positive regulation of steroid biosynthetic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Regulation of actin cytoskeleton organization Source: Ensembl
Regulation of nitric-oxide synthase activity Source: GO_Central
Regulation of sensory perception of pain Source: Ensembl
Response to copper ion Source: UniProtKB
Response to gamma radiation Source: Ensembl
Response to hypoxia Source: Ensembl
Response to L-ascorbic acid Source: Ensembl
Response to organonitrogen compound Source: Ensembl
Response to ozone Source: Ensembl
Spermatogenesis Source: Ensembl