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IL1A Matched Antibody Pair (620) (APMAB-620LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IL1A polyclonal antibody, 100 ug
Detection Antibody
Anti-IL1A Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
Alternative Names
Interleukin 1 Alpha
Entrez Gene ID
3552
UniProt ID
P01583
More Infomation

Maculewicz, E., Antkowiak, B., Antkowiak, O., Borecka, A., Mastalerz, A., Leońska-Duniec, A., ... & Cięszczyk, P. (2022). The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters. BMC genomics, 23(1), 1-12.

Leon, K. E., Buj, R., Lesko, E., Dahl, E. S., Chen, C. W., Tangudu, N. K., ... & Aird, K. M. (2021). DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. Journal of Cell Biology, 220(8), e202008101.

Harati-Sadegh, M., Sargazi, S., Khorasani, M., Ansari-Moghaddam, A., Mirinejad, S., Sheervalilou, R., & Saravani, R. (2021). IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis. Ophthalmic Genetics, 42(5), 503-513.

Li, M., Yang, J., Liu, K., Yang, J., Zhan, X., Wang, L., ... & Mao, Z. (2020). p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis. Journal of Cancer, 11(6), 1457.

Xia, H., Chen, Y., Meng, J., & Liang, C. (2019). Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects. Artificial cells, nanomedicine, and biotechnology, 47(1), 3138-3152.

Li, H., Duan, N., Zhang, Q., & Shao, Y. (2019). IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han population. International Immunopharmacology, 76, 105869.

Ji, H., Lu, L., Huang, J., Liu, Y., Zhang, B., Tang, H., ... & Lu, H. (2019). IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study. BMC cancer, 19(1), 1-8.

Hashemi, M., Bahari, G., Sarhadi, S., Eskandari, E., Narouie, B., Taheri, M., & Ghavami, S. (2018). 4‐bp insertion/deletion (rs3783553) polymorphism within the 3′ UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian population. Journal of cellular biochemistry, 119(3), 2627-2635.

Tanaka, Y., Uchi, H., Hashimoto-Hachiya, A., & Furue, M. (2018). Tryptophan photoproduct FICZ upregulates IL1A, IL1B, and IL6 expression via oxidative stress in keratinocytes. Oxidative medicine and cellular longevity, 2018.

Oliveira, M. B., de Vasconcellos, J. P. C., Ananina, G., Costa, V. P., & de Melo, M. B. (2018). Association between IL1A and IL1B polymorphisms and primary open angle glaucoma in a Brazilian population. Experimental Biology and Medicine, 243(13), 1083-1091.

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For research use only. Not intended for any clinical use.

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