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Mouse Anti-IL1A Recombinant Antibody (CBYY-I1467) (CBMAB-I2637-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYY-I1467
Antibody Isotype
IgG2a, κ
Application
WB, IF

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 1 Alpha
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Entrez Gene ID
Human3552
Mouse16175
UniProt ID
HumanP01583
MouseP01582
Alternative Names
Interleukin 1 Alpha
Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Biological Process
Apoptotic process Source: ProtInc
Cellular response to heat Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Cellular sodium ion homeostasis Source: Ensembl
Connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
Cytokine-mediated signaling pathway Source: BHF-UCL
Ectopic germ cell programmed cell death Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Fever generation Source: UniProtKB-KW
Heart development Source: Ensembl
Immune response Source: InterPro
Inflammatory response Source: GO_Central
Keratinization Source: Ensembl
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of establishment of Sertoli cell barrier Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cytokine production Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Positive regulation of immature T cell proliferation in thymus Source: GO_Central
Positive regulation of interleukin-2 production Source: BHF-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of JNK cascade Source: Ensembl
Positive regulation of mitotic nuclear division Source: BHF-UCL
Positive regulation of neutrophil migration Source: Ensembl
Positive regulation of prostaglandin secretion Source: Ensembl
Positive regulation of protein secretion Source: AgBase
Positive regulation of steroid biosynthetic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Regulation of actin cytoskeleton organization Source: Ensembl
Regulation of nitric-oxide synthase activity Source: GO_Central
Regulation of sensory perception of pain Source: Ensembl
Response to copper ion Source: UniProtKB
Response to gamma radiation Source: Ensembl
Response to hypoxia Source: Ensembl
Response to L-ascorbic acid Source: Ensembl
Response to organonitrogen compound Source: Ensembl
Response to ozone Source: Ensembl
Spermatogenesis Source: Ensembl
More Infomation

Maculewicz, E., Antkowiak, B., Antkowiak, O., Borecka, A., Mastalerz, A., Leońska-Duniec, A., ... & Cięszczyk, P. (2022). The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters. BMC genomics, 23(1), 1-12.

Leon, K. E., Buj, R., Lesko, E., Dahl, E. S., Chen, C. W., Tangudu, N. K., ... & Aird, K. M. (2021). DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. Journal of Cell Biology, 220(8), e202008101.

Harati-Sadegh, M., Sargazi, S., Khorasani, M., Ansari-Moghaddam, A., Mirinejad, S., Sheervalilou, R., & Saravani, R. (2021). IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis. Ophthalmic Genetics, 42(5), 503-513.

Li, M., Yang, J., Liu, K., Yang, J., Zhan, X., Wang, L., ... & Mao, Z. (2020). p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis. Journal of Cancer, 11(6), 1457.

Xia, H., Chen, Y., Meng, J., & Liang, C. (2019). Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects. Artificial cells, nanomedicine, and biotechnology, 47(1), 3138-3152.

Li, H., Duan, N., Zhang, Q., & Shao, Y. (2019). IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han population. International Immunopharmacology, 76, 105869.

Ji, H., Lu, L., Huang, J., Liu, Y., Zhang, B., Tang, H., ... & Lu, H. (2019). IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study. BMC cancer, 19(1), 1-8.

Hashemi, M., Bahari, G., Sarhadi, S., Eskandari, E., Narouie, B., Taheri, M., & Ghavami, S. (2018). 4‐bp insertion/deletion (rs3783553) polymorphism within the 3′ UTR of IL1A contributes to the risk of prostate cancer in a sample of Iranian population. Journal of cellular biochemistry, 119(3), 2627-2635.

Tanaka, Y., Uchi, H., Hashimoto-Hachiya, A., & Furue, M. (2018). Tryptophan photoproduct FICZ upregulates IL1A, IL1B, and IL6 expression via oxidative stress in keratinocytes. Oxidative medicine and cellular longevity, 2018.

Oliveira, M. B., de Vasconcellos, J. P. C., Ananina, G., Costa, V. P., & de Melo, M. B. (2018). Association between IL1A and IL1B polymorphisms and primary open angle glaucoma in a Brazilian population. Experimental Biology and Medicine, 243(13), 1083-1091.

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For research use only. Not intended for any clinical use.

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