VIPR2

Vasoactive intestinal peptide (VIP; MIM 192320) and pituitary adenylate cyclase activating polypeptide (PACAP; MIM 102980) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP and PACAP share homology, they differ in their substrate specificities and expression patterns. See VIPR1 (MIM 192321) and ADCYAP1R1(MIM 102981).[supplied by OMIM

Full Name

vasoactive intestinal peptide receptor 2

Function

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Biological Process

Biological Process activation of adenylate cyclase activity Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:InterPro
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 24-126
Helical: 127-151
Cytoplasmic: 152-158
Helical: 159-178
Extracellular: 179-203
Helical: 204-227
Cytoplasmic: 228-240
Helical: 241-262
Extracellular: 263-279
Helical: 280-303
Cytoplasmic: 304-328
Helical: 329-348
Extracellular: 349-360
Helical: 361-380
Cytoplasmic: 381-438