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Rabbit Anti-VIPR2 Monoclonal Antibody (SP235) (CBMAB-1714-YC)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
SP235
Antibody Isotype
IgG
Application
FC, IHC-P

Basic Information

Immunogen
Synthetic peptide within Human VPAC2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vasoactive intestinal peptide receptor 2
Introduction
VIPR2 is a receptor for VIP as well as PACAP-38 and -27, the activity of VIPR2 is mediated by G proteins which activate adenylyl cyclase.
Entrez Gene ID
7434
UniProt ID
P41587
Alternative Names
receptor for vasoactive intestinal polypeptide (VIP); may mediate gonadotropin actions in the ovary, may be involved with patterning during development
Function
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
Biological Process
Biological Process activation of adenylate cyclase activity Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:InterPro
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 24-126
Helical: 127-151
Cytoplasmic: 152-158
Helical: 159-178
Extracellular: 179-203
Helical: 204-227
Cytoplasmic: 228-240
Helical: 241-262
Extracellular: 263-279
Helical: 280-303
Cytoplasmic: 304-328
Helical: 329-348
Extracellular: 349-360
Helical: 361-380
Cytoplasmic: 381-438
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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