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Mouse Anti-VIPR2 Recombinant Antibody (2E3) (CBMAB-1589-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
VIPR2 (NP_003373, 24-127aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vasoactive intestinal peptide receptor 2
Introduction
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.
Entrez Gene ID
7434
UniProt ID
P41587
Alternative Names
Vasoactive Intestinal Peptide Receptor 2; Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor; Helodermin-Preferring VIP Receptor; VIP And PACAP Receptor 2; PACAP Type III Receptor; PACAP-R-3; PACAP-R3; VIP-R-2;
Function
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
Biological Process
Biological Process activation of adenylate cyclase activity Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:InterPro
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 24-126
Helical: 127-151
Cytoplasmic: 152-158
Helical: 159-178
Extracellular: 179-203
Helical: 204-227
Cytoplasmic: 228-240
Helical: 241-262
Extracellular: 263-279
Helical: 280-303
Cytoplasmic: 304-328
Helical: 329-348
Extracellular: 349-360
Helical: 361-380
Cytoplasmic: 381-438
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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