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Mouse Anti-VIPR2 Recombinant Antibody (2G9) (CBMAB-A9884-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G9
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
VIPR2 (AAH10569.1, 1 a.a. ~ 438 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
vasoactive intestinal peptide receptor 2
Introduction
Vasoactive intestinal peptide (VIP; MIM 192320) and pituitary adenylate cyclase activating polypeptide (PACAP; MIM 102980) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP and PACAP share homology, they differ in their substrate specificities and expression patterns. See VIPR1 (MIM 192321) and ADCYAP1R1(MIM 102981).[supplied by OMIM
Entrez Gene ID
7434
UniProt ID
P41587
Alternative Names
FLJ16511; VPAC2; VPCAP2R
Function
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
Biological Process
Biological Process activation of adenylate cyclase activity Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process cell surface receptor signaling pathway Source:InterPro
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 24-126
Helical: 127-151
Cytoplasmic: 152-158
Helical: 159-178
Extracellular: 179-203
Helical: 204-227
Cytoplasmic: 228-240
Helical: 241-262
Extracellular: 263-279
Helical: 280-303
Cytoplasmic: 304-328
Helical: 329-348
Extracellular: 349-360
Helical: 361-380
Cytoplasmic: 381-438
More Infomation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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