PLIN2

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.

perilipin 2

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Long-chain fatty acid transportIEA:Ensembl
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Response to organic cyclic compoundIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl

Membrane
Lipid droplet

Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.