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Mouse Anti-PLIN2 Recombinant Antibody (AP125) (CBMAB-A4668-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat
Clone
AP125
Antibody Isotype
IgG1
Application
IHC-Fr, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues 5-27 from N-terminus of human adipophilin
Specificity
Human, Dog, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized and reconstitute with sterile dH2O
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
perilipin 2
Introduction
PLIN2 belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, i
Entrez Gene ID
Mouse123
Rat298199
Dog100856329
UniProt ID
MouseQ99541
RatQ5U2U5
DogE2RP20
Alternative Names
ADFP; ADRP
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Long-chain fatty acid transportIEA:Ensembl
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Response to organic cyclic compoundIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Membrane
Lipid droplet
PTM
Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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