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Mouse Anti-PLIN2 Antibody (10BA6) (CBMAB-1489CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
10BA6
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
perilipin 2
Introduction
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. Diseases associated with PLIN2 include Lipid-Rich Carcinoma and Epithelial-Myoepithelial Carcinoma. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
Entrez Gene ID
123
UniProt ID
Q99541
Alternative Names
Perilipin 2; Adipose Differentiation-Related Protein; ADFP; adipophilin; ADRP;
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Long-chain fatty acid transportIEA:Ensembl
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Response to organic cyclic compoundIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Membrane
Lipid droplet
PTM
Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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