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Mouse Anti-PLIN2 Recombinant Antibody (ADFP/1493) (CBMAB-P2129-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
ADFP/1493
Antibody Isotype
IgG2b, λ
Application
ELISA, IHC-P, IF, ICC

Basic Information

Immunogen
Recombinant human Adipophilin protein fragment (aa249-376)
Specificity
Human
Antibody Isotype
IgG2b, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
10 mM PBS with 0.05% BSA and 0.05% azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
perilipin 2
Introduction
PLIN2 belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
Entrez Gene ID
123
UniProt ID
Q99541
Alternative Names
ADFP; ADRP
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Biological Process
Cellular response to glucose starvationManual Assertion Based On ExperimentIDA:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Lipid storageManual Assertion Based On ExperimentIDA:UniProtKB
Long-chain fatty acid transportIEA:Ensembl
Positive regulation of sequestering of triglycerideManual Assertion Based On ExperimentIBA:GO_Central
Response to organic cyclic compoundIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Membrane
Lipid droplet
PTM
Acylated; primarily with C14, C16 and C18 fatty acids.
Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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