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EPB41

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Full Name
Erythrocyte Membrane Protein Band 4.1
Research Area
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actomyosin structure organization Source: GO_Central
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cortical actin cytoskeleton organization Source: InterPro
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein localization to cell cortex Source: UniProtKB
Protein-containing complex assembly Source: Ensembl
Regulation of calcium ion transport Source: UniProtKB
Regulation of cell shape Source: CAFA
Regulation of intestinal absorption Source: UniProtKB
Cellular Location
Nucleus; Cytoskeleton; Cell cortex
Involvement in disease
Elliptocytosis 1 (EL1):
A Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
PTM
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.

Anti-EPB41 antibodies

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Target: EPB41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D9
Application*: WB, E
Target: EPB41
Host: Mouse
Specificity: human
Clone: A-4
Application*: WB, IP, IF, E
Target: EPB41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1026
Application*: E, IF, WB
Target: EPB41
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0925
Application*: WB, P, F
Target: EPB41
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0924
Application*: E, IF, P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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