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Mouse Anti-EPB41 Recombinant Antibody (3D9) (CBMAB-A2632-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EPB41 (AAH39079, 116 a.a. ~ 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Erythrocyte Membrane Protein Band 4.1
Introduction
Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene (MIM 182860), the beta-spectrin gene (MIM 182870), or the band 3 gene (MIM 109270).[supplied by OMIM
Entrez Gene ID
2035
UniProt ID
P11171
Alternative Names
4.1R; EL1; HE
Research Area
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actomyosin structure organization Source: GO_Central
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cortical actin cytoskeleton organization Source: InterPro
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein localization to cell cortex Source: UniProtKB
Protein-containing complex assembly Source: Ensembl
Regulation of calcium ion transport Source: UniProtKB
Regulation of cell shape Source: CAFA
Regulation of intestinal absorption Source: UniProtKB
Cellular Location
Nucleus; Cytoskeleton; Cell cortex
Involvement in disease
Elliptocytosis 1 (EL1):
A Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
PTM
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
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For research use only. Not intended for any clinical use.

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