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Mouse Anti-EPB41 (AA 116-226) Recombinant Antibody (CBFYE-0924) (CBMAB-E1401-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0924
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
EPB41 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: IEFGTSLDEE IILKAPIAAP EPELKTDPSL DLHSLSSAET QPAQEELRED PDFEIKEGEG LEECSKIEVK EESPQSKAET ELKASQKPIR KHRNMHCKVS LLDDTVYECV
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 116-226

Target

Full Name
Erythrocyte Membrane Protein Band 4.1
Introduction
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
2035
UniProt ID
P11171
Alternative Names
Erythrocyte Membrane Protein Band 4.1; Elliptocytosis 1, RH-Linked; Band 4.1; EPB4.1; 4.1R; P4.1
Research Area
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actomyosin structure organization Source: GO_Central
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cortical actin cytoskeleton organization Source: InterPro
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein localization to cell cortex Source: UniProtKB
Protein-containing complex assembly Source: Ensembl
Regulation of calcium ion transport Source: UniProtKB
Regulation of cell shape Source: CAFA
Regulation of intestinal absorption Source: UniProtKB
Cellular Location
Nucleus; Cytoskeleton; Cell cortex
Involvement in disease
Elliptocytosis 1 (EL1):
A Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
PTM
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
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For research use only. Not intended for any clinical use.

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