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CFLAR

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Full Name
CASP8 And FADD Like Apoptosis Regulator
Function
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Apoptotic process Source: UniProtKB
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to nitric oxide Source: Ensembl
Negative regulation of apoptotic process Source: ProtInc
Negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
Negative regulation of cellular response to transforming growth factor beta stimulus Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Negative regulation of hepatocyte apoptotic process Source: Ensembl
Negative regulation of myoblast fusion Source: BHF-UCL
Negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of extracellular matrix organization Source: Ensembl
Positive regulation of glomerular mesangial cell proliferation Source: Ensembl
Positive regulation of hepatocyte proliferation Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
Regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
Regulation of necroptotic process Source: UniProtKB
Regulation of skeletal muscle satellite cell proliferation Source: BHF-UCL
Regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
Response to testosterone Source: Ensembl
Skeletal muscle atrophy Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Skeletal muscle tissue regeneration Source: BHF-UCL
Skeletal myofibril assembly Source: BHF-UCL
Viral process Source: UniProtKB-KW
Wound healing Source: BHF-UCL
Cellular Location
Cytosol; Ripoptosome; CD95 death-inducing signaling complex; Death-inducing signaling complex; Cytoplasm; Membrane raft
PTM
Proteolytically processed by CASP8 generating subunit p43 and p12.

Anti-CFLAR antibodies

+ Filters
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Target: CFLAR
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 5D8
Application*: WB, E
Target: CFLAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1261
Application*: WB
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0115
Application*: WB, IP, IF, E
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-2130
Application*: E, IF, IP, WB
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3599
Application*: E, WB, P
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-2555
Application*: WB, IH
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F12
Application*: E, IC/IF, P, WB
Target: CFLAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-2745
Application*: E, IH, WB, F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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