CFLAR Matched Antibody Pair (267) (APMAB-267LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-CFLAR monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-CFLAR Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Alternative Names

CASP8 And FADD Like Apoptosis Regulator; Caspase-Like Apoptosis Regulatory Protein; CASP8 And FADD-Like Apoptosis Regulator; Cellular FLICE-Like Inhibitory Protein; FADD-Like Antiapoptotic Molecule 1; MACH-Related Inducer Of Toxicity; Caspase-Eight-Related Protein; Inhibitor Of FLICE; Caspase Homolog; CASP8AP1; FLAME-1; I-FLICE; Casper; C-FLIP;

Entrez Gene ID

8837

UniProt ID

O15519

More Infomation

References

Xiaohong, W., Jun, Z., Hongmei, G., & Fan, Q. (2019). CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress. Biomedicine & Pharmacotherapy, 117, 109155.

Li, M., An, W., Xu, L., Lin, Y., Su, L., & Liu, X. (2019). The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR L in human lung cancer cells. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Wang, P. X., Ji, Y. X., Zhang, X. J., Zhao, L. P., Yan, Z. Z., Zhang, P., ... & Li, H. (2017). Correction: Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. Nature medicine, 23(10), 1241-1241.

Zhuge, B., & Li, G. (2017). MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator. Biochemical and biophysical research communications, 494(3-4), 687-692.

Wang, P. X., Ji, Y. X., Zhang, X. J., Zhao, L. P., Yan, Z. Z., Zhang, P., ... & Li, H. (2017). Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. Nature medicine, 23(4), 439-449.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Rabbit Anti-CFLAR Recombinant Antibody (CBXF-1261)

Mouse Anti-CFLAR Recombinant Antibody (CBXF-2555)

Mouse Anti-CFLAR Recombinant Antibody (CBXF-0115)

Mouse Anti-CFLAR Recombinant Antibody (CBXF-3599)

Mouse Anti-CFLAR Recombinant Antibody (CBXF-2745)

Mouse Anti-CFLAR Recombinant Antibody (CBXF-2130)

Mouse Anti-CFLAR Recombinant Antibody (5D8)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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