CBY1

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chibby Family Member 1, Beta Catenin Antagonist

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

Cardiac muscle cell differentiation Source: UniProtKB
Cell projection organization Source: UniProtKB-KW
Fat cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: UniProtKB
Protein homotetramerization Source: CAFA
Protein localization Source: UniProtKB

Golgi apparatus; Trans-Golgi network; Cilium basal body; Centriole; Nucleus speckle