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Mouse Anti-CBY1 Recombinant Antibody (C2325) (CBMAB-C2325-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C2325
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-126 representing full length Chibby of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chibby Family Member 1, Beta Catenin Antagonist
Introduction
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human25776
Mouse73739
UniProt ID
HumanQ9Y3M2
MouseQ9D1C2
Alternative Names
Chibby Family Member 1, Beta Catenin Antagonist; PKD2 Interactor, Golgi And Endoplasmic Reticulum-Associated 1; Chibby CTNNB1-Mediated Transcription Inhibitor; Cytosolic Leucine-Rich Protein; ARPP-Binding Protein; PIGEA-14; C22orf2; PGEA1; ARB1; CBY;
Function
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Biological Process
Cardiac muscle cell differentiation Source: UniProtKB
Cell projection organization Source: UniProtKB-KW
Fat cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: UniProtKB
Protein homotetramerization Source: CAFA
Protein localization Source: UniProtKB
Cellular Location
Golgi apparatus; Trans-Golgi network; Cilium basal body; Centriole; Nucleus speckle
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For research use only. Not intended for any clinical use.

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