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Mouse Anti-CBY1 Recombinant Antibody (2F2) (CBMAB-C5067-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F2
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
CBY1 (18 a.a. ~ 126 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chibby Family Member 1, Beta Catenin Antagonist
Introduction
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
25776
UniProt ID
Q9Y3M2
Alternative Names
Chibby Family Member 1, Beta Catenin Antagonist; PKD2 Interactor, Golgi And Endoplasmic Reticulum-Associated 1; Chibby CTNNB1-Mediated Transcription Inhibitor; Cytosolic Leucine-Rich Protein; ARPP-Binding Protein; PIGEA-14; C22orf2; PGEA1; ARB1; CBY;
Function
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Biological Process
Cardiac muscle cell differentiation Source: UniProtKB
Cell projection organization Source: UniProtKB-KW
Fat cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: UniProtKB
Protein homotetramerization Source: CAFA
Protein localization Source: UniProtKB
Cellular Location
Golgi apparatus; Trans-Golgi network; Cilium basal body; Centriole; Nucleus speckle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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