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CAPNS1

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Full Name
calpain, small subunit 1
Function
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Biological Process
Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm; Cell membrane. Translocates to the plasma membrane upon calcium binding.

Anti-CAPNS1 antibodies

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Target: CAPNS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0803
Application*: WB, P, F
Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0802
Application*: IP, IF, WB
Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D11
Application*: E, WB, IF
Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBLNC-140
Application*: WB, IP
Target: CAPNS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C9695
Application*: WB, IH, F, IF
Target: CAPNS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: 156
Application*: IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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