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Mouse Anti-CAPNS1 Recombinant Antibody (CBLNC-140) (CBMAB-1312-CN)


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Published Data
CBMAB-1312-CN-1
Mouse Anti-CAPNS1 Recombinant Antibody (CBLNC-140) (CBMAB-1312-CN) in WB
Western blot analysis of the calpain regulatory subunit after exposure to TGFβ and/or hypoxia for 8 h. ...View More
Cui, W., Zhou, J., Dehne, N., & Brüne, B. (2015). Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages. Cell & bioscience, 5, 1-12.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBLNC-140
Antibody Isotype
IgG2b, κ
Application
WB, IP

Basic Information

Immunogen
Amino acids 92-104 of Calpain reg of Calpain of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calpain, small subunit 1
Introduction
Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. CAPNS1 is a member of the calpain small subunit family, which is essential for the stability and function of both calpain heterodimers. The proteolytic activities of CAPNS1 influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy.
Entrez Gene ID
Human826
Cattle281664
UniProt ID
HumanP04632
CattleP13135
Alternative Names
CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4
Function
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Biological Process
Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm; Cell membrane. Translocates to the plasma membrane upon calcium binding.
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For research use only. Not intended for any clinical use.

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