CA8

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.

CA8

Does not have a carbonic anhydrase catalytic activity.

One-carbon metabolic process Source: GO_Central
Phosphatidylinositol-mediated signaling Source: Ensembl

Cytoplasm

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3): A congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mental retardation.