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Rabbit Anti-CA8 Recombinant Antibody (001) (CBMAB-C1441-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
001
Antibody Isotype
IgG
Application
E

Basic Information

Immunogen
Recombinant Mouse Carbonic Anhydrase VIII / CA8 protein.
Host Species
Rabbit
Specificity
Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CA8
Entrez Gene ID
767
UniProt ID
P28651
Function
Does not have a carbonic anhydrase catalytic activity.
Biological Process
One-carbon metabolic process Source: GO_Central
Phosphatidylinositol-mediated signaling Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3): A congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mental retardation.
More Infomation

Chi, T. H., Hsieh, B. Y., Liang, P. S., Han, T. H., & Hsieh, M. (2021). Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells. Cellular and Molecular Neurobiology, 41(6), 1355-1371.

Mamoor, S. (2021). Carbonic anhydrase VIII (CA8) is a differentially expressed gene in brain metastatic human breast cancer.

Paternoster, L., Soblet, J., Aeby, A., De Tiège, X., Goldman, S., Yue, W. W., ... & Deconinck, N. (2020). Novel homozygous variant of carbonic anhydrase 8 gene expanding the phenotype of cerebellar ataxia, mental retardation, and disequilibrium syndrome subtype 3. American Journal of Medical Genetics Part A, 182(11), 2685-2693.

Sanyanga, T. A., & Tastan Bishop, Ö. (2020). Structural characterization of carbonic anhydrase VIII and effects of missense single nucleotide variations to protein structure and function. International journal of molecular sciences, 21(8), 2764.

Hsieh, M., Hsieh, B. Y., Ma, C. Y., Li, Y. T., Liu, C. S., & Lo, C. M. (2019). Protective roles of carbonic anhydrase 8 in Machado–Joseph Disease. Journal of neuroscience research, 97(10), 1278-1297.

Lo, C. M., Ma, Y. S., Wei, Y. H., Hsieh, B. Y., & Hsieh, M. (2018). Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model. Archives of biochemistry and biophysics, 641, 50-61.

Zhuang, G. Z., Upadhyay, U., Tong, X., Kang, Y., Erasso, D. M., Fu, E. S., ... & Levitt, R. C. (2018). Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. Gene therapy, 25(4), 297-311.

Paternoster, L., Soblet, J., Aeby, A., Vilain, C., Smits, G., & Deconinck, N. (2017). A new mutation of carbonic anhydrase 8 gene expanding the cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ) subtype 3. J Neurol Sci, 381, 1136-7.

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For research use only. Not intended for any clinical use.

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