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Mouse Anti-CA8 Recombinant Antibody (1BA9) (CBMAB-1041CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1BA9
Antibody Isotype
IgG2a
Application
E

Basic Information

Immunogen
Recombinant Human Carbonic Anhydrase VIIICA8 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CA8
Introduction
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Diseases associated with CA8 include Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 3 and Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1.
Entrez Gene ID
767
UniProt ID
P35219
Alternative Names
CALS; CARP; CA-RP; CAMRQ3; CA-VIII
Function
Does not have a carbonic anhydrase catalytic activity.
Biological Process
One-carbon metabolic process Source: GO_Central
Phosphatidylinositol-mediated signaling Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3): A congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mental retardation.
More Infomation

Chi, T. H., Hsieh, B. Y., Liang, P. S., Han, T. H., & Hsieh, M. (2021). Expression and Functional Study of Single Mutations of Carbonic Anhydrase 8 in Neuronal Cells. Cellular and Molecular Neurobiology, 41(6), 1355-1371.

Mamoor, S. (2021). Carbonic anhydrase VIII (CA8) is a differentially expressed gene in brain metastatic human breast cancer.

Paternoster, L., Soblet, J., Aeby, A., De Tiège, X., Goldman, S., Yue, W. W., ... & Deconinck, N. (2020). Novel homozygous variant of carbonic anhydrase 8 gene expanding the phenotype of cerebellar ataxia, mental retardation, and disequilibrium syndrome subtype 3. American Journal of Medical Genetics Part A, 182(11), 2685-2693.

Sanyanga, T. A., & Tastan Bishop, Ö. (2020). Structural characterization of carbonic anhydrase VIII and effects of missense single nucleotide variations to protein structure and function. International journal of molecular sciences, 21(8), 2764.

Hsieh, M., Hsieh, B. Y., Ma, C. Y., Li, Y. T., Liu, C. S., & Lo, C. M. (2019). Protective roles of carbonic anhydrase 8 in Machado–Joseph Disease. Journal of neuroscience research, 97(10), 1278-1297.

Lo, C. M., Ma, Y. S., Wei, Y. H., Hsieh, B. Y., & Hsieh, M. (2018). Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model. Archives of biochemistry and biophysics, 641, 50-61.

Zhuang, G. Z., Upadhyay, U., Tong, X., Kang, Y., Erasso, D. M., Fu, E. S., ... & Levitt, R. C. (2018). Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. Gene therapy, 25(4), 297-311.

Paternoster, L., Soblet, J., Aeby, A., Vilain, C., Smits, G., & Deconinck, N. (2017). A new mutation of carbonic anhydrase 8 gene expanding the cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ) subtype 3. J Neurol Sci, 381, 1136-7.

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For research use only. Not intended for any clinical use.

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