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Mouse Anti-TRDMT1 Recombinant Antibody (CBYJT-4586) (CBMAB-T4105-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4586
Antibody Isotype
IgG1, λ
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant full length TRDMT1 (DNMT2) (aa 1-392) fused to a GST tag
Specificity
Human
Antibody Isotype
IgG1, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-392

Target

Full Name
TRDMT1 Gene(Protein Coding) TRNA Aspartic Acid Methyltransferase 1
Introduction
TRDMT1 is a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. TRDMT1 also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, TRDMT1 is distinct and highly conserved in its function among taxa.
Entrez Gene ID
1787
UniProt ID
O14717
Alternative Names
TRNA Aspartic Acid Methyltransferase 1; DNA (Cytosine-5)-Methyltransferase-Like Protein 2; TRNA (Cytosine(38)-C(5))-Methyltransferase; DNA MTase Homolog HsaIIP; PUMET; DNMT2; DNA (Cytosine-5-)-Methyltransferase 2; TRNA (Cytosine-5-)-Methyltransferase; DNA Methyltransferase Homolog HsaIIP; DNA Cytosine-5 Methyltransferase 2
Function
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Biological Process
Biological Process response to amphetamine Source:Ensembl
Biological Process tRNA C5-cytosine methylation Source:GO_Central1 Publication
Biological Process tRNA methylation Source:MGI1 Publication
Biological Process tRNA modification Source:Reactome
Biological Process tRNA stabilization Source:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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