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Rabbit Anti-ATOH1 Recombinant Antibody (BA0315) (CBMAB-0113CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0315
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from residues in Human HATH1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATOH1
Introduction
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. Flora et al. (2009) showed that Atoh1 regulates the signal transduction pathway of sonic hedgehog, an extracellular factor that is essential for granule neuron precursor proliferation, and demonstrated that deletion of Atoh1 prevents cerebellar neoplasia in a mouse model of medulloblastoma. Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
Entrez Gene ID
Human474
Mouse11921
Rat500156
UniProt ID
HumanQ92858
MouseP48985
RatD3ZQL9
Alternative Names
Atonal BHLH Transcription Factor 1; Atonal Homolog BHLH Transcription Factor 1; Class A Basic Helix-Loop-Helix Protein 14; Helix-Loop-Helix Protein HATH-1; BHLHa14; HATH1; ATH1; Atonal Homolog 1 (Drosophila); Atonal Homolog 1; MATH-1
Function
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Biological Process
Auditory receptor cell fate determination Source: Ensembl
Auditory receptor cell fate specification Source: Ensembl
Axon guidance Source: Ensembl
Central nervous system development Source: ProtInc
Cerebral cortex development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Neuron differentiation Source: GO_Central
Neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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