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Mouse Anti-ATOH1 Recombinant Antibody (18A6) (CBMAB-0876-YC)


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Published Data
Mouse Anti-ATOH1 Recombinant Antibody (18A6) (CBMAB-0876-YC) in WB
The expression of Atoh1 was assessed by western blot analysis. ...View More
Yu, X., Li, S., Xu, Y., Zhang, Y., Ma, W., Liang, C., ... & Li, J. (2020). Androgen maintains intestinal homeostasis by inhibiting BMP signaling via intestinal stromal cells. Stem Cell Reports, 15(4), 912-925.
Mouse Anti-ATOH1 Recombinant Antibody (18A6) (CBMAB-0876-YC) in IP
Co-immunoprecipitation (coIP) analysis of nuclear extracts from E17.5 cochleae or 293 cells cotransfected with indicated plasmids. Antibodies used for IP or for western detection are indicated. Anti-HA or -Flag was used for immunoprecipitating HA-Atoh1 or Flag-Pou4f3/Flag-Gfi1 fusion protein. ...View More
Li, J., Zhang, T., Ramakrishnan, A., Fritzsch, B., Xu, J., Wong, E. Y., ... & Xu, P. X. (2020). Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. Nucleic acids research, 48(6), 2880-2896.
Mouse Anti-ATOH1 Recombinant Antibody (18A6) (CBMAB-0876-YC) in IF
Representative images of Math1 staining in WT and VGFoverexpressing mice. Scale bar = 100 µm. ...View More
Mizoguchi, T., Shimazawa, M., Ohuchi, K., Kuse, Y., Nakamura, S., & Hara, H. (2019). Impaired cerebellar development in mice overexpressing VGF. Neurochemical Research, 44, 374-387.

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
18A6
Antibody Isotype
IgG1, κ
Application
IP, WB

Basic Information

Immunogen
Amino acids 2-189 of MATH-1 of human origin.
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATOH1
Introduction
ATOH1 (math1 (Atoh1)) belongs to the basic helix-loop-helix (BHLH) family of transcription factors, which activates E-box dependent transcription along with E47. ATOH1 is required for the formation of both neural and non-neural cell types. ATOH1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells.
Entrez Gene ID
11921
UniProt ID
P48985
Alternative Names
Ath1
Function
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Biological Process
Auditory receptor cell fate determination Source: Ensembl
Auditory receptor cell fate specification Source: Ensembl
Axon guidance Source: Ensembl
Central nervous system development Source: ProtInc
Cerebral cortex development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Neuron differentiation Source: GO_Central
Neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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