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Mouse Anti-ATOH1 Recombinant Antibody (1A8) (CBMAB-A3984-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
ATOH1 (NP_005163, 1-130 aa) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATOH1
Introduction
ATOH1 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
Entrez Gene ID
474
UniProt ID
Q92858
Alternative Names
Atonal BHLH Transcription Factor 1; Atonal Homolog BHLH Transcription Factor 1; Class A Basic Helix-Loop-Helix Protein 14; Helix-Loop-Helix Protein HATH-1; BHLHa14; HATH1;
Function
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Biological Process
Auditory receptor cell fate determination Source: Ensembl
Auditory receptor cell fate specification Source: Ensembl
Axon guidance Source: Ensembl
Central nervous system development Source: ProtInc
Cerebral cortex development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Neuron differentiation Source: GO_Central
Neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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