ZHX2

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq]

ZHX2

Acts as a transcriptional repressor (PubMed:12741956).
Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956).
May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity).
In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

Biological Process mRNA catabolic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retinal bipolar neuron differentiation Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl

Nucleus
Colocalizes with EFNB1 intracellular domain in the nucleus.