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Rabbit Anti-ZHX2 (phosphorylated Ser338) Recombinant Antibody (56A6') (PTM-CBMAB-R4227-CN)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
56A6'
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Ser338 of human c-Raf, conjugated to KLH
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM Sodium HEPES, pH 7.5, 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol

Target

Full Name
ZHX2
Introduction
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human22882
Mouse387609
Rat314988
Monkey708694
UniProt ID
HumanQ9Y6X8
MouseQ8C0C0
RatQ80VX4
MonkeyH9ERC0
Function
Acts as a transcriptional repressor (PubMed:12741956).
Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956).
May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity).
In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Biological Process
Biological Process mRNA catabolic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retinal bipolar neuron differentiation Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl
Cellular Location
Nucleus
Colocalizes with EFNB1 intracellular domain in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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