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Mouse Anti-ZHX2 Recombinant Antibody (CBWJZ-089) (CBMAB-Z0254-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-089
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
ZHX2
Introduction
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
Entrez Gene ID
22882
UniProt ID
Q9Y6X8
Alternative Names
KIAA0854
Function
Acts as a transcriptional repressor (PubMed:12741956).
Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956).
May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity).
In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Biological Process
Biological Process mRNA catabolic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retinal bipolar neuron differentiation Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl
Cellular Location
Nucleus
Colocalizes with EFNB1 intracellular domain in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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