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WTAP

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq]
Full Name
WTAP
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081).
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process mRNA methylation Source:UniProtKB3 Publications
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing Source:UniProtKB-KW
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.

Anti-WTAP antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B11
Application*: IP, E
Target: WTAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A4
Application*: IP, E
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6H3
Application*: WB, IH
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C3
Application*: WB, IH
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: WB
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-097
Application*: WB, IH
Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJW-082
Application*: E, WB, IH
Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-081
Application*: WB, P
Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJW-041
Application*: SE, P, E, WB
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B6B8
Application*: E, WB, P, F
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6B6B6
Application*: E, WB, P, IF, F
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJW-211
Application*: E, IF, IH, WB, siRNA
Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12G6
Application*: P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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