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Mouse Anti-WTAP Recombinant Antibody (CBWJW-041) (CBMAB-W0195-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJW-041
Antibody Isotype
IgG2a, к
Application
S-ELISA, IHC-P, ELISA, WB

Basic Information

Immunogen
WTAP (NP_690596.1, aa70-151) partial recombinant protein with GST tag. MW of the GST tag alone is 26 Kda.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WTAP
Introduction
WTAP is a protein-coding gene which appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Diseases associated with WTAP include Wilms Tumor 1. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.
Entrez Gene ID
9589
UniProt ID
Q15007
Alternative Names
Mum2
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081).
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process mRNA methylation Source:UniProtKB3 Publications
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing Source:UniProtKB-KW
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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