Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-WTAP Recombinant Antibody (CBWJW-211) (CBMAB-W0106-WJ)


See all WTAP antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJW-211
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB, siRNA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WTAP
Introduction
WTAP is a protein-coding gene which appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Diseases associated with WTAP include Wilms Tumor 1. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.
Entrez Gene ID
Human9589
Mouse60532
Rat499020
UniProt ID
HumanQ15007
MouseQ9ER69
RatD3ZPY0
Alternative Names
Mum2
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081).
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process mRNA methylation Source:UniProtKB3 Publications
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing Source:UniProtKB-KW
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-WTAP Recombinant Antibody (CBWJW-211)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry