WDR5

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

WD Repeat Domain 5

Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960).
May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852).
May regulate osteoblasts differentiation (By similarity).
In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Biological Process gluconeogenesis Source:Ensembl
Biological Process histone H3 acetylation Source:BHF-UCL1 Publication
Biological Process histone H3-K14 acetylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 methylation Source:GO_Central1 Publication
Biological Process histone H4-K16 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K5 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K8 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process neuron projection development Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of gluconeogenesis Source:Ensembl
Biological Process positive regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of cell division Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of dosage compensation by inactivation of X chromosome Source:ComplexPortal
Biological Process regulation of embryonic development Source:ComplexPortal
Biological Process regulation of histone deacetylation Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylation Source:ComplexPortal1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication

Nucleus