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Rabbit Anti-WDR5 Recombinant Antibody (D3X5B) (CBMAB-W0320-WJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle
Clone
D3X5B
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Cattle
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD Repeat Domain 5
Introduction
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.
Entrez Gene ID
Human11091
Mouse140858
Rat362093
Cattle100125836
Monkey722123
UniProt ID
HumanP61964
MouseP61965
RatQ498M4
CattleQ2KIG2
MonkeyF7AMK0
Alternative Names
SWD3
Function
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960).
May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852).
May regulate osteoblasts differentiation (By similarity).
In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Biological Process gluconeogenesis Source:Ensembl
Biological Process histone H3 acetylation Source:BHF-UCL1 Publication
Biological Process histone H3-K14 acetylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 methylation Source:GO_Central1 Publication
Biological Process histone H4-K16 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K5 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K8 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process neuron projection development Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of gluconeogenesis Source:Ensembl
Biological Process positive regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of cell division Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of dosage compensation by inactivation of X chromosome Source:ComplexPortal
Biological Process regulation of embryonic development Source:ComplexPortal
Biological Process regulation of histone deacetylation Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylation Source:ComplexPortal1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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