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Mouse Anti-WDR5 Recombinant Antibody (1B1) (CBMAB-W0029-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B1
Antibody Isotype
IgG2a, к
Application
ELISA

Basic Information

Immunogen
WDR5 (NP_060058, aa16-120) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: QPTPSSSATQ SKPTPVKPNY ALKFTLAGHT KAVSSVKFSP NGEWLASSSA DKLIKIWGAY DGKFEKTISG HKLGISDVAW SSDSNLLVSA SDDKTLKIWD VSSGK
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD Repeat Domain 5
Introduction
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.
Entrez Gene ID
11091
UniProt ID
P61964
Alternative Names
SWD3
Function
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960).
May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852).
May regulate osteoblasts differentiation (By similarity).
In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Biological Process gluconeogenesis Source:Ensembl
Biological Process histone H3 acetylation Source:BHF-UCL1 Publication
Biological Process histone H3-K14 acetylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 methylation Source:GO_Central1 Publication
Biological Process histone H4-K16 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K5 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K8 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process neuron projection development Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of gluconeogenesis Source:Ensembl
Biological Process positive regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of cell division Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of dosage compensation by inactivation of X chromosome Source:ComplexPortal
Biological Process regulation of embryonic development Source:ComplexPortal
Biological Process regulation of histone deacetylation Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylation Source:ComplexPortal1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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