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WBP2

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq]
Full Name
WW domain binding protein 2
Function
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533).
In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533).
Required for YAP1 coactivation function on PGR activity (PubMed:16772533).
Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).
Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Biological Process
Biological Process cellular response to estrogen stimulus Source:UniProtKB1 Publication
Biological Process establishment of protein localization to chromatin Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of histone H3-K14 acetylation Source:UniProtKB1 Publication
Biological Process positive regulation of intracellular estrogen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process progesterone receptor signaling pathway Source:UniProtKB1 Publication
Biological Process response to estrogen Source:UniProtKB1 Publication
Biological Process response to progesterone Source:UniProtKB1 Publication
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Translocates from cytoplasm to nucleus when phosphorylated.
Involvement in disease
Deafness, autosomal recessive, 107 (DFNB107):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones (PubMed:21642474).
Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation (PubMed:21642474).

Anti-WBP2 antibodies

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Target: WBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B1
Application*: WB, E
Target: WBP2
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBYY-1624
Application*: WB, IP, IF, E
Target: WBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1611
Application*: E, IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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