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Mouse Anti-WBP2 Recombinant Antibody (CBYY-1624) (CBMAB-1695-YY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYY-1624
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WW domain binding protein 2
Introduction
CD163L1 (CD163 Molecule Like 1) is a Protein Coding gene. An important paralog of this gene is CD163.
Entrez Gene ID
Human23558
Mouse22378
Rat192645
UniProt ID
HumanQ969T9
MouseP97765
RatQ8R478
Alternative Names
CD163 Molecule Like 1; CD163 Antigen-Like 1; CD163B; M160; Scavenger Receptor Cysteine-Rich Type 1 Protein M160; CD163 Molecule-Like 1;
Function
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533).
In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533).
Required for YAP1 coactivation function on PGR activity (PubMed:16772533).
Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).
Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Biological Process
Biological Process cellular response to estrogen stimulus Source:UniProtKB1 Publication
Biological Process establishment of protein localization to chromatin Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of histone H3-K14 acetylation Source:UniProtKB1 Publication
Biological Process positive regulation of intracellular estrogen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process progesterone receptor signaling pathway Source:UniProtKB1 Publication
Biological Process response to estrogen Source:UniProtKB1 Publication
Biological Process response to progesterone Source:UniProtKB1 Publication
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Translocates from cytoplasm to nucleus when phosphorylated.
Involvement in disease
Deafness, autosomal recessive, 107 (DFNB107):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones (PubMed:21642474).
Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation (PubMed:21642474).
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For research use only. Not intended for any clinical use.

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