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Mouse Anti-WBP2 Recombinant Antibody (CBYY-1611) (CBMAB-1682-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1611
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
WBP2 (AAH10616, 1 a.a. ~ 261 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV YMPTSQPPPP PYYPPEDKKT Q
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WW domain binding protein 2
Introduction
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]
Entrez Gene ID
23558
UniProt ID
Q969T9
Alternative Names
WW Domain Binding Protein 2; WBP-2; WW Domain-Binding Protein 2; DFNB107; GRAMD6;
Function
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533).
In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533).
Required for YAP1 coactivation function on PGR activity (PubMed:16772533).
Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).
Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Biological Process
Biological Process cellular response to estrogen stimulus Source:UniProtKB1 Publication
Biological Process establishment of protein localization to chromatin Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of histone H3-K14 acetylation Source:UniProtKB1 Publication
Biological Process positive regulation of intracellular estrogen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process progesterone receptor signaling pathway Source:UniProtKB1 Publication
Biological Process response to estrogen Source:UniProtKB1 Publication
Biological Process response to progesterone Source:UniProtKB1 Publication
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Translocates from cytoplasm to nucleus when phosphorylated.
Involvement in disease
Deafness, autosomal recessive, 107 (DFNB107):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones (PubMed:21642474).
Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation (PubMed:21642474).
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For research use only. Not intended for any clinical use.

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