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UBTF

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM
Full Name
upstream binding transcription factor, RNA polymerase I
Function
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Biological Process
Biological Process positive regulation of transcription by RNA polymerase I Source:UniProtKB
Biological Process transcription by RNA polymerase I Source:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase I promoter Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus, nucleolus
Involvement in disease
Neurodegeneration, childhood-onset, with brain atrophy (CONDBA):
An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
PTM
Phosphorylated and activated by PIK3CA.

Anti-UBTF antibodies

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 6C6
Application*: WB, E
Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2D8
Application*: WB, E
Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2C6
Application*: WB, E
Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-619178
Application*: WB, E
Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6B6
Application*: E, IC, IF, P, WB
Target: UBTF
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYU-242
Application*: WB, IP, IF, P, E
Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-241
Application*: E, IC, IH, WB
Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYU-240
Application*: E, IF, P, WB
Target: UBTF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYU-239
Application*: F, IC, IH, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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