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Rabbit Anti-UBTF Recombinant Antibody (CBFYU-239) (CBMAB-U0239-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYU-239
Antibody Isotype
IgG
Application
FC, ICC, IHC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to human UBF at N-terminal
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50 mM Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% BSA, 40% Glycerol
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
upstream binding transcription factor, RNA polymerase I
Introduction
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions.
Entrez Gene ID
Human7343
Mouse21429
UniProt ID
HumanP17480
MouseP25976
Alternative Names
UBF; UBF1; UBF2; UBF-1; CONDBA; NOR-90
Function
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Biological Process
Biological Process positive regulation of transcription by RNA polymerase I Source:UniProtKB
Biological Process transcription by RNA polymerase I Source:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase I promoter Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus, nucleolus
Involvement in disease
Neurodegeneration, childhood-onset, with brain atrophy (CONDBA):
An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
PTM
Phosphorylated and activated by PIK3CA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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